Abstract: In order to suppress the spread of malicious programs in heterogeneous wireless sensor networks (HWSNs), a HWSNs offensive and defensive game is proposed based on the differences in node energy and computing power. The mixed Nash equilibrium of the attacking and defending sides was obtained through calculation, and the differential equations of the node conversion of the attacking and defending sides were established by combining the differential game. The dynamic evolution law of the proportion of malicious nodes was analyzed. Combined with numerical experimental analysis, the method to effectively suppress the spread of HWSNs malicious programs was verified.