Abstract: Aiming at the current computer virus propagation modeling research that does not comprehensively consider the impact of security protection and continuous virus updates, this paper proposes a computer virus SEIR (susceptible-exposed-infected-recovery) propagation model with switching characteristics and immune control. Considering the impact of security protection measures and virus updates, a switching virus propagation model was constructed, which was composed of a low protection subsystem and a high protection subsystem. Considering the immune control strategy, a switching pulse virus propagation model was constructed. In order to verify the effectiveness of the model, numerical simulations were performed on the BA scale-free network and the SW small-world network, and a comparative analysis was carried out. The experimental results show that the immune control strategy in the SW small world network can effectively control the spread of the virus; the ratio of the low-protection transmission period to the high-protection transmission period is smaller, the density of latent nodes and infected nodes is smaller when it reaches a plateau. The longer the update cycle, the lower the peak density of latent nodes and infected nodes.